EPA Method 506

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EPA Method 506:
Determination of Phthalate and Adipate Esters in Drinking Water by Liquid-Liquid Extraction or Liquid-Solid Extraction and Gas Chromatography with Photoionization Detection - Revision 1.1.

Samples are extracted using liquid/liquid extraction (LLE) or liquid/solid extraction (LSE). For LLE, a 1-L sample is extracted with methylene chloride followed by hexane using a glass separatory funnel, and the final extract is dried and reduced to a to a volume of 1-mL. For LSE a measured volume of sample is extracted with a LSE cartridge or disk, and eluted using acetonitrile and methylene chloride (or pure methylene chloride), and the eluent/extract is reduced to a volume of 1-mL. The concentrations of esters in the extracts are measured using a gas chromatography (GC) system equipped with a photoionization detector (PID).

This method determines certain phthalate and adipate esters in drinking water.

Methods for the Determination of Organic Compounds in Drinking Water - Supplement III (EPA/600/R-95-131)

(A) Phthalate ester interference: Avoid the use of plastics and use pure reagents to avoid contamination by these ubiquitous compounds.(B) Glassware contamination: Thoroughly clean glassware, including baking or solvent rinse.(C) Reagent contamination: Use high purity reagents.(D) Extracted interferences: Interference from extracted non-target compounds, with retention times similar to target compounds, can be reduced by cleaning the extract.(E) Variable solvents: Use the same solvent for each analysis.

QC Requirements:
Initial demonstration of laboratory capability, followed by analysis of laboratory reagent blanks (LRB), laboratory fortified blanks (LFB), laboratory fortified sample matrix (LFM), and quality control samples (QCS). A MDL for each analyte must also be determined. Additional quality control practices are recommended.

Maximum Holding Time:
Samples must be extracted within 14 days. Extracts can be held for an additional 14 days prior to analysis.



Ranges differ for each analyte depending on matrix and instrumentation.

Precision and accuracy values determined using single laboratory data from six to seven replicate measurements of fortified reagent water. NOTE: Data represents performance using liquid-liquid extraction. Performance data for liquid-solid extraction also are available.

MDLs were determined using the standard deviation of 6 replicate analyses of an analyte-fortified reagent water sample multiplied by the t-value for 5 degrees of freedom at the 99% confidence level. Detailed instructions for how MDLs are determined are found at 40 CFR part 136, Appendix B.

Revision Number:
Revision 1.1, 1995